June 2022
University of Cambridge is collecting samples for study of idiopathic epilepsy in border collies.
https://www.canine-genetics.org.uk/wp-content/uploads/2021/09/Border_Collie_Epilepsy_Flyer_UoC_2021.pdf
https://www.canine-genetics.org.uk/wp-content/uploads/2021/09/Border_Collie_Epilepsy_Flyer_UoC_2021.pdf
July 2019
Dear friends and colleagues,
The AHT’s idiopathic epilepsy research team is investigating the genetics of idiopathic epilepsy in the Border Collie and Italian Spinone.
If you or any of your clients would like to contribute to our research by submitting a DNA sample of a Border Collie or Italian Spinone diagnosed with IE, or would like further information on our research, then please contact Donna Foster at the Animal Health Trust:
[email protected] [mailto:[email protected]]or click this link:
https://www.aht.org.uk/research/epilepsy[https://www.aht.org.uk/research/epilepsy].
Thank you!
Luisa
--
Luisa De Risio
DVM (Hons), PhD, DECVN, FRCVS, RCVS and
EBVS®European
Specialist in
Veterinary Neurology
Head of Neurology/ Neurosurgery Unit
Head of Research- Clinics
Animal Health Trust,
Lanwades Park, Kentford,Newmarket, Suffolk, CB8 7UU
Switchboard: 01638 552700
Reg Charity No 209642
The AHT’s idiopathic epilepsy research team is investigating the genetics of idiopathic epilepsy in the Border Collie and Italian Spinone.
If you or any of your clients would like to contribute to our research by submitting a DNA sample of a Border Collie or Italian Spinone diagnosed with IE, or would like further information on our research, then please contact Donna Foster at the Animal Health Trust:
[email protected] [mailto:[email protected]]or click this link:
https://www.aht.org.uk/research/epilepsy[https://www.aht.org.uk/research/epilepsy].
Thank you!
Luisa
--
Luisa De Risio
DVM (Hons), PhD, DECVN, FRCVS, RCVS and
EBVS®European
Specialist in
Veterinary Neurology
Head of Neurology/ Neurosurgery Unit
Head of Research- Clinics
Animal Health Trust,
Lanwades Park, Kentford,Newmarket, Suffolk, CB8 7UU
Switchboard: 01638 552700
Reg Charity No 209642
October 2016
Use of Accelerometry to Detect Seizure Activity in Dogs with Idiopathic Epilepsy
North Carolina State University - College of Veterinary Medicine (NCSU-CVM)
Morris Animal Foundation has recently awarded veterinary neurologist Karen R. Munana, DVM, DACVIM, with a 3 year grant to study the “Use of Accelerometry to Detect Seizure Activity in Dogs with Idiopathic Epilepsy.” This study is co-sponsored by Toby’s Foundation. If you meet the criteria please consider being part of this study.
Epilepsy is a common problem in dogs that typically requires lifelong medical attention. However, the majority of dogs do not become seizure free with treatment, and a consistent source of worry for caregivers is the risk of seizures occurring while a dog is left unattended. This study will evaluate the
use of a commercially available, collar mounted accelerometer (Whistle Activity Monitor®) to reliably detect seizure activity in epileptic dogs. The availability of an easily worn, inexpensive device to detect seizures will provide valuable data to help veterinarians make informed treatment decisions, and reduce the risk of injury or death from unobserved seizures for their canine patients.
Recruitment Criteria:
• Dogs with idiopathic epilepsy that are experiencing an average 3 or more generalized seizures per month despite appropriate treatment
• Age at onset of seizures - 6 months to 6 years, with a 1 year documented history of seizures
• Owners must have access to a Smartphone and wireless internet in their home
• Owners must be willing to travel to NC State University College of Veterinary Medicine for 3 study-related visits over a 6 month period.
• Physical and neurological examination for their dog at no cost
• Bloodwork and urinalysis at no cost, to exclude an underlying cause for the seizures if not already performed in the past.
• Use of the Whistle activity monitor and home video monitoring system for the 6 month study period
Recruiting for Patients: 10/15/2015 thru 10/15/2017
CONTACT: Julie Nettifee, RVT, BS, VTS (Neurology) | [email protected] | 919-513-6812
North Carolina State University - College of Veterinary Medicine (NCSU-CVM)
Morris Animal Foundation has recently awarded veterinary neurologist Karen R. Munana, DVM, DACVIM, with a 3 year grant to study the “Use of Accelerometry to Detect Seizure Activity in Dogs with Idiopathic Epilepsy.” This study is co-sponsored by Toby’s Foundation. If you meet the criteria please consider being part of this study.
Epilepsy is a common problem in dogs that typically requires lifelong medical attention. However, the majority of dogs do not become seizure free with treatment, and a consistent source of worry for caregivers is the risk of seizures occurring while a dog is left unattended. This study will evaluate the
use of a commercially available, collar mounted accelerometer (Whistle Activity Monitor®) to reliably detect seizure activity in epileptic dogs. The availability of an easily worn, inexpensive device to detect seizures will provide valuable data to help veterinarians make informed treatment decisions, and reduce the risk of injury or death from unobserved seizures for their canine patients.
Recruitment Criteria:
• Dogs with idiopathic epilepsy that are experiencing an average 3 or more generalized seizures per month despite appropriate treatment
• Age at onset of seizures - 6 months to 6 years, with a 1 year documented history of seizures
• Owners must have access to a Smartphone and wireless internet in their home
• Owners must be willing to travel to NC State University College of Veterinary Medicine for 3 study-related visits over a 6 month period.
• Physical and neurological examination for their dog at no cost
• Bloodwork and urinalysis at no cost, to exclude an underlying cause for the seizures if not already performed in the past.
• Use of the Whistle activity monitor and home video monitoring system for the 6 month study period
Recruiting for Patients: 10/15/2015 thru 10/15/2017
CONTACT: Julie Nettifee, RVT, BS, VTS (Neurology) | [email protected] | 919-513-6812
October 2016
The Microbact-Gut-Brain Axis In Canine Epilepsy-Determining The Role Of Lactobacilli
North Carolina State University - College of Veterinary Medicine (NCSU-CVM)
North Carolina State University is seeking potential candidates for this study. They are looking for canines with epilepsy who are not currently receiving treatment and lives with another dog who does not have epilepsy. The primary faculty working on this research is Dr. Karen Munana and Dr. Megan Jacobs. This research is funded by the AKC-Canine Health Foundation.
From NCSU-CVM's website: "Epilepsy is the most common nervous system disorder of dogs, affecting up to 0.75% of the canine population. Alterations in the population of intestinal bacteria in the Lactbacillus group are believed to play a role in the development and progression of several human diseases of the nervous system. The purpose of this trial is to evaluate bacterial populations in the gastrointestinal tract of dogs with epilepsy and compare these to normal dogs."
A link to the study is provided below;
https://cvm.ncsu.edu/research/clinical-trials/list/?specialty=neurology
If you have any additional questions or have potential candidates who would be willing to take part in this research, please contact Ashley Hershey at [email protected] or Julie Nettifee at [email protected].
North Carolina State University - College of Veterinary Medicine (NCSU-CVM)
North Carolina State University is seeking potential candidates for this study. They are looking for canines with epilepsy who are not currently receiving treatment and lives with another dog who does not have epilepsy. The primary faculty working on this research is Dr. Karen Munana and Dr. Megan Jacobs. This research is funded by the AKC-Canine Health Foundation.
From NCSU-CVM's website: "Epilepsy is the most common nervous system disorder of dogs, affecting up to 0.75% of the canine population. Alterations in the population of intestinal bacteria in the Lactbacillus group are believed to play a role in the development and progression of several human diseases of the nervous system. The purpose of this trial is to evaluate bacterial populations in the gastrointestinal tract of dogs with epilepsy and compare these to normal dogs."
A link to the study is provided below;
https://cvm.ncsu.edu/research/clinical-trials/list/?specialty=neurology
If you have any additional questions or have potential candidates who would be willing to take part in this research, please contact Ashley Hershey at [email protected] or Julie Nettifee at [email protected].
November 2014
Canine Idiopathic Epilepsy: A questionnaire study of the impact of Pexion (Imepitoin) on canine behaviour and welfare
The Royal Veterinary College at the University of London is looking for participation in a questionnaire study for epileptic dogs currently taking Pexion (Imepitioin). A link to the survey is provided below. https://www.surveymonkey.com/s/rvcepilepsypexionstudy Please email feel free to email Dr. Rowena Packer with any questions you may have regarding the study ([email protected]) |
October 2014
Keppra (Levetiracetam extended release) XR Pharmacokinetic project
North Carolina State University - College of Veterinary Medicine (NCSU-CVM)
Epilepsy Research Cases Needed
We are seeking dogs on Keppra XR for a project evaluating the drug levels in dogs over a 12 hour period. Ideally dogs will be located close to NC State, however we will consider other patients if the referring DVM can assist with collection. For this project we are recruiting dogs on Keppra XR, Keppra XR and Phenobarbital and/or Keppra XR and Zonisamide. Dogs will have 4 blood samples drawn over a 12-hour period.
For more information or to have your pet considered for the project
please email [email protected] or call 919-513-6812.
Thanks for your assistance!
Julie Ann Nettifee Osborne, RVT, BS, VTS (Neurology)
North Carolina State University - College of Veterinary Medicine (NCSU-CVM)
Epilepsy Research Cases Needed
We are seeking dogs on Keppra XR for a project evaluating the drug levels in dogs over a 12 hour period. Ideally dogs will be located close to NC State, however we will consider other patients if the referring DVM can assist with collection. For this project we are recruiting dogs on Keppra XR, Keppra XR and Phenobarbital and/or Keppra XR and Zonisamide. Dogs will have 4 blood samples drawn over a 12-hour period.
For more information or to have your pet considered for the project
please email [email protected] or call 919-513-6812.
Thanks for your assistance!
Julie Ann Nettifee Osborne, RVT, BS, VTS (Neurology)
The AKC Canine Health Foundation Commits $268,000 to Combat Epilepsy and Hypothyroidism in Dogs
See more at: http://www.akcchf.org/news-events/news/chf-awards-epilepsy-hypothyroidism-grants.html#sthash.v9knabqC.bYaVC1Fw.dpuf
See more at: http://www.akcchf.org/news-events/news/chf-awards-epilepsy-hypothyroidism-grants.html#sthash.v9knabqC.bYaVC1Fw.dpuf
October 2013
High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs
Abstract
A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote, and G/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9%) in Border Collies. The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies.
Keijiro Mizukami, Akira Yabuki, Hye-Sook Chang, et al., “High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs,” Disease Markers, vol. 35, no. 6, Article ID 695918, 4 pages, 2013. doi:10.1155/2013/695918
PDF Link to full article
Abstract
A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote, and G/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9%) in Border Collies. The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies.
Keijiro Mizukami, Akira Yabuki, Hye-Sook Chang, et al., “High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs,” Disease Markers, vol. 35, no. 6, Article ID 695918, 4 pages, 2013. doi:10.1155/2013/695918
PDF Link to full article